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TargetCollagenase 3
LigandBDBM30371
Substrate/CompetitorMMP-13 Substrate
Meas. Tech.Determination of MMP-13 Activity
Temperature298.15±n/a K
IC50 4.0±n/a nM
Commentsextracted
Citation Monovich LGTommasi RAFujimoto RABlancuzzi VClark KCornell WDDoti RDoughty JFang JFarley DFitt JGanu VGoldberg RGoldstein RLavoie SKulathila RMacchia WParker DTMelton RO'Byrne EPastor GPellas TQuadros EReel NRoland DMSakane YSingh HSkiles JSomers JToscano KWigg AZhou SZhu LShieh WCXue SMcQuire LW Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem 52:3523-38 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Collagenase 3
Name:Collagenase 3
Synonyms:MMP-13 | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:Enzyme
Mol. Mass.:53808.06
Organism:Homo sapiens (Human)
Description:P45452
Residue:471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30371
MMP-13 Substrate
Name:MMP-13 Substrate
Synonyms:n/a
Type:Fluorogenic Substrate
Mol. Mass.:2571.45
Organism:n/a
Description:n/a
Residue:24
Sequence:
MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-CONH2