| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [T204D] |
|---|
| Ligand | BDBM396738 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  Ding, P; Gelman, M; Kinsella, T; Singh, R; Bhamidipati, S; Velaparthi, U; Borzilleri, RM; Rahaman, H; Warrier, JS GDF-8 inhibitors US Patent US9981944 Publication Date 5/29/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 [T204D] |
|---|
| Name: | TGF-beta receptor type-1 [T204D] |
|---|
| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 55981.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36897[T204D] |
|---|
| Residue: | 503 |
|---|
| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM396738 |
|---|
| n/a |
|---|
| Name | BDBM396738 |
|---|
| Synonyms: | 6-(6'-(difluoromethyl)-5-fluoro-[2,2'-bipyridin]- 3-yl)imidazo[1,2-a]pyridine-3-carboxamide | US9981944, Example 84 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H12F3N5O |
|---|
| Mol. Mass. | 383.3267 |
|---|
| SMILES | NC(=O)c1cnc2ccc(cn12)-c1cc(F)cnc1-c1cccc(n1)C(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
