Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM31220 |
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Substrate/Competitor | 6-FAM labeled octapeptide |
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Meas. Tech. | Fluorescence Polarization (FP) Binding Assay |
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pH | 7.4±n/a |
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Temperature | 296.15±n/a K |
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Ki | 600±n/a nM |
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Citation | Zhang, R; Mayhood, T; Lipari, P; Wang, Y; Durkin, J; Syto, R; Gesell, J; McNemar, C; Windsor, W Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction. Anal Biochem331:138-46 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM31220 |
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6-FAM labeled octapeptide |
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Name: | 6-FAM labeled octapeptide |
Synonyms: | n/a |
Type: | fluorescent peptide |
Mol. Mass.: | 2832.21 |
Organism: | n/a |
Description: | Fluorophore 6-carboxyfluorescein was covalently attached to the side chain amino group of the Dpr residue in the peptide. |
Residue: | 26 |
Sequence: | Ac-Phe-Arg-Dpr-Ac6c-(6-Br)Trp-Glu-Glu-Leu-NH2
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