| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynurenine--oxoglutarate transaminase 1 |
|---|
| Ligand | BDBM31881 |
|---|
| Substrate/Competitor | BDBM31880 |
|---|
| Meas. Tech. | hKAT-I Activity Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 311.15±n/a K |
|---|
| IC50 | 220000±220000 nM |
|---|
| Citation |  Han, Q; Robinson, H; Cai, T; Tagle, DA; Li, J Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K. J Med Chem52:2786-93 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Kynurenine--oxoglutarate transaminase 1 |
|---|
| Name: | Kynurenine--oxoglutarate transaminase 1 |
|---|
| Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
|---|
| Type: | Aminotransferase; Lyase |
|---|
| Mol. Mass.: | 47874.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
|---|
| Residue: | 422 |
|---|
| Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
|
|
|
|---|
| BDBM31881 |
|---|
| BDBM31880 |
|---|
| Name | BDBM31881 |
|---|
| Synonyms: | DL-indole-3-lactic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H11NO3 |
|---|
| Mol. Mass. | 205.2099 |
|---|
| SMILES | OC(Cc1c[nH]c2ccccc12)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
