Reaction Details |
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Target | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Ligand | BDBM31960 |
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Substrate/Competitor | BDBM8737 |
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Meas. Tech. | Enzymatic Inhibition Assay |
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IC50 | 2130±n/a nM |
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Citation | He, L; Zhang, L; Liu, X; Li, X; Zheng, M; Li, H; Yu, K; Chen, K; Shen, X; Jiang, H; Liu, H Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem52:2465-81 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Name: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
Synonyms: | (3R)-hydroxymyristoyl ACP dehydrase | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase | FABZ_HELPY | beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) | fabZ |
Type: | Lyase |
Mol. Mass.: | 18198.05 |
Organism: | Helicobacter pylori (Campylobacter pylori) |
Description: | HpfabZ is expressed and purified from E. coli. |
Residue: | 159 |
Sequence: | MEQSHQNLQSQFFIEHILQILPHRYPMLLVDRIIELQANKKIVAYKNITFNEDVFNGHFP
NKPIFPGVLIVEGMAQTGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLE
YHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERD
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BDBM31960 |
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BDBM8737 |
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Name | BDBM31960 |
Synonyms: | carbohydrazide derivative, 5c |
Type | Small organic molecule |
Emp. Form. | C16H8Br2F6N2O3 |
Mol. Mass. | 550.045 |
SMILES | Oc1c(Br)cc(C=NNC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(O)c1Br |w:6.5| |
Structure |
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