| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1424-1463]/[1502-1685] |
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| Ligand | BDBM33260 |
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| Substrate/Competitor | BDBM33263 |
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| Meas. Tech. | Protease Inhibition Assay |
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| pH | 8.5±n/a |
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| Temperature | 296.15±n/a K |
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| Ki | 337000±56000 nM |
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| Citation |  Ganesh, VK; Muller, N; Judge, K; Luan, CH; Padmanabhan, R; Murthy, KH Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem13:257-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Genome polyprotein [1424-1463]/[1502-1685] |
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| Name: | Genome polyprotein [1424-1463]/[1502-1685] |
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| Synonyms: | WNV CF40.Gly.NS3Pro | WNV NS2B(H):NS3 | West Nile Virus (WNV) NS2B-NS3 Protease |
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| Type: | Cofactor/Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | It is the catalytically active recombinant WNV protease, consisting of a 40-residue component of cofactor NS2B tethered via a nonapeptide (G4SG4) to the N-terminal 184 residues of NS3. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Genome polyprotein [1424-1463] |
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| Synonyms: | Flavivirin protease NS2B regulatory subunit | NS2B | POLG_WNV |
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| Type: | Cofactor Domain |
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| Mol. Mass.: | 4431.59 |
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| Organism: | West Nile virus (WNV) |
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| Description: | P06935[1424-1463] |
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| Residue: | 40 |
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| Sequence: | IERTADITWESDAEITGSSERVDVRLDDDGNFQLMNDPGA
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| Component 2 |
| Name: | Genome polyprotein [1502-1685] |
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| Synonyms: | Flavivirin protease NS3 catalytic subunit | NS3 | POLG_WNV |
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| Type: | Catalytic Subunit |
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| Mol. Mass.: | 19839.27 |
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| Organism: | West Nile virus (WNV) |
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| Description: | P06935[1502-1685] |
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| Residue: | 184 |
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| Sequence: | GGVLWDTPSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAALMS
GEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVKNVQTKPGVFKTPE
GEIGAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGERMEEPAPAGFE
PEML
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| BDBM33260 |
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| BDBM33263 |
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| Name | BDBM33260 |
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| Synonyms: | biguanidine, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H10N8 |
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| Mol. Mass. | 170.1758 |
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| SMILES | [#7]-[#6](=[#7])-[#7]-[#7]=[#6]-[#6]=[#7]\[#7]=[#6](\[#7])-[#7] |w:4.3,6.5| |
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| Structure | 
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