| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN3 |
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| Ligand | BDBM107700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EGLN-1 Activity Assay |
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| IC50 | 52300±n/a nM |
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| Citation |  Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent US Patent
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN3 |
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| Name: | Prolyl hydroxylase EGLN3 |
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| Synonyms: | EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3) |
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| Type: | Protein |
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| Mol. Mass.: | 27265.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H6Z9 |
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| Residue: | 239 |
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| Sequence: | MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
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| BDBM107700 |
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| n/a |
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| Name | BDBM107700 |
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| Synonyms: | US11426393, Compound Table XV.6 | US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2- carbonyl)-amino]-acetic acid methyl ester | US9598370, Example 00131 | USRE47437, Example [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2-carbonyl)-amino]-acetic acid methyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O4 |
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| Mol. Mass. | 300.3092 |
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| SMILES | COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1 |
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| Structure | 
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