| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM35217 |
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| Substrate/Competitor | BDBM35191 |
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| Meas. Tech. | Caspase-3 Inhibition Assay |
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| pH | 7.2±n/a |
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| Temperature | 296.15±n/a K |
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| IC50 | 1503±159 nM |
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| Citation |  Havran, LM; Chong, DC; Childers, WE; Dollings, PJ; Dietrich, A; Harrison, BL; Marathias, V; Tawa, G; Aulabaugh, A; Cowling, R; Kapoor, B; Xu, W; Mosyak, L; Moy, F; Hum, WT; Wood, A; Robichaud, AJ 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3. Bioorg Med Chem17:7755-68 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM35217 |
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| BDBM35191 |
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| Name | BDBM35217 |
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| Synonyms: | pyrimidoindolone, 22f |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O4S |
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| Mol. Mass. | 399.463 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)Nc1ccc2N3CC(C)(C)CN=C3C(=O)c2c1 |c:23| |
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| Structure | 
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