| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-3 |
|---|
| Ligand | BDBM35219 |
|---|
| Substrate/Competitor | BDBM35191 |
|---|
| Meas. Tech. | Caspase-3 Inhibition Assay |
|---|
| pH | 7.2±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| IC50 | 2394±140 nM |
|---|
| Citation |  Havran, LM; Chong, DC; Childers, WE; Dollings, PJ; Dietrich, A; Harrison, BL; Marathias, V; Tawa, G; Aulabaugh, A; Cowling, R; Kapoor, B; Xu, W; Mosyak, L; Moy, F; Hum, WT; Wood, A; Robichaud, AJ 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3. Bioorg Med Chem17:7755-68 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Caspase-3 |
|---|
| Name: | Caspase-3 |
|---|
| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
|---|
| Type: | Hydrolase; heterotetramer of two heterodimers |
|---|
| Mol. Mass.: | 31607.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 277 |
|---|
| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
|
|
|
|---|
| BDBM35219 |
|---|
| BDBM35191 |
|---|
| Name | BDBM35219 |
|---|
| Synonyms: | pyrimidoindolone, 22h |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18FN3O3S |
|---|
| Mol. Mass. | 387.428 |
|---|
| SMILES | CC1(C)CN=C2N(C1)c1ccc(NS(=O)(=O)c3ccc(F)cc3)cc1C2=O |c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
