| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity nerve growth factor receptor |
|---|
| Ligand | BDBM136638 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Omnia Assay |
|---|
| IC50 | 3.10±n/a nM |
|---|
| Citation |  Haas, J; Andrews, SW; Jiang, Y; Zhang, G Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds US Patent US10005783 Publication Date 6/26/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity nerve growth factor receptor |
|---|
| Name: | High affinity nerve growth factor receptor |
|---|
| Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 87498.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04629 |
|---|
| Residue: | 796 |
|---|
| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
|
|
|
|---|
| BDBM136638 |
|---|
| n/a |
|---|
| Name | BDBM136638 |
|---|
| Synonyms: | US10005783, 55 | US10047097, 55 | US10774085, Example 55 | US11267818, Example 55 | US8865698, 55 | US9676783, 55 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23F2N7OS |
|---|
| Mol. Mass. | 483.537 |
|---|
| SMILES | CC(C)Nc1nc(cs1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
