| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
|---|
| Ligand | BDBM35666 |
|---|
| Substrate/Competitor | BDBM35667 |
|---|
| Meas. Tech. | Binding Assay for Human V2 Receptor |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| Ki | 9.7±n/a nM |
|---|
| Citation |  Tsukamoto, I; Koshio, H; Orita, M; Saitoh, C; Yanai-Inamura, H; Kitada-Nozawa, C; Yamamoto, E; Yatsu, T; Sakamoto, S; Tsukamoto, S Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes. Bioorg Med Chem17:8161-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Vasopressin V2 receptor |
|---|
| Name: | Vasopressin V2 receptor |
|---|
| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 40295.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30518 |
|---|
| Residue: | 371 |
|---|
| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
|
|
|
|---|
| BDBM35666 |
|---|
| BDBM35667 |
|---|
| Name | BDBM35666 |
|---|
| Synonyms: | BMC173130 Compound 1t | benzazepinelidene acetamide derivative, 1b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23ClF2N4O3 |
|---|
| Mol. Mass. | 500.925 |
|---|
| SMILES | Cc1ccn(n1)-c1ccc(C(=O)N2CCC(F)(F)\C(=C/C(=O)NCCO)c3ccccc23)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
