| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
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| Ligand | BDBM35854 |
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| Substrate/Competitor | BDBM35847 |
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| Meas. Tech. | Prostanoid EP Receptor Binding Assay |
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| Ki | 16±n/a nM |
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| EC50 | 50±n/a nM |
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| Citation |  Asada, M; Obitsu, T; Nagase, T; Sugimoto, I; Yamaura, Y; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists. Bioorg Med Chem17:6567-82 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Prostaglandin E2 receptor EP3 subtype |
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| Name: | Prostaglandin E2 receptor EP3 subtype |
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| Synonyms: | PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3 |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 40092.50 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 365 |
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| Sequence: | MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
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| BDBM35854 |
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| BDBM35847 |
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| Name | BDBM35854 |
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| Synonyms: | acrylic acid derivative, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O3 |
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| Mol. Mass. | 398.4538 |
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| SMILES | OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1OCCc1ccc2ccccc2c1 |
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| Structure | 
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