Reaction Details |
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Target | Prostaglandin E2 receptor EP3 subtype |
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Ligand | BDBM35863 |
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Substrate/Competitor | BDBM35847 |
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Meas. Tech. | Prostanoid EP Receptor Binding Assay |
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Ki | 260±n/a nM |
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EC50 | 2600±n/a nM |
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Citation | Asada, M; Obitsu, T; Nagase, T; Sugimoto, I; Yamaura, Y; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists. Bioorg Med Chem17:6567-82 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Prostaglandin E2 receptor EP3 subtype |
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Name: | Prostaglandin E2 receptor EP3 subtype |
Synonyms: | PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3 |
Type: | G-protein coupled receptor |
Mol. Mass.: | 40092.50 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 365 |
Sequence: | MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
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BDBM35863 |
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BDBM35847 |
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Name | BDBM35863 |
Synonyms: | phenoxyacetic acid analogue, 19 |
Type | Small organic molecule |
Emp. Form. | C24H22N2O4 |
Mol. Mass. | 402.4425 |
SMILES | OC(=O)COc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 |
Structure |
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