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TargetCathepsin B
LigandBDBM36325
Substrate/CompetitorBDBM36388
Meas. Tech.Assay name: Protease Inhibition Assay
pH5.5±0
Temperature310.15±0 K
IC50 1.2e+3± 0 nM
Citation Kato DBoatright KMBerger ABNazif TBlum GRyan CChehade KASalvesen GSBogyo M Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-8 (2005) [PubMed]  Article
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Cathepsin B
Name:Cathepsin B
Synonyms:n/a
Type:Protein
Mol. Mass.:37463.53
Organism:Rattus norvegicus
Description:P00787
Residue:339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCG
TVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDR
ICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCL
PYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIM
AEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSW
NVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
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BDBM36325
BDBM36388
NameBDBM36325
Synonyms:Cathepsin Inhibitor III
TypeSmall organic molecule
Emp. Form.C27H27N3O7
Mol. Mass.505.5192
SMILESCOc1ccc(cc1)C(=O)ONC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Structure
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