| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Nef/Tyrosine-protein kinase HCK |
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| Ligand | BDBM14807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| Temperature | 298.15±0 K |
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| IC50 | 5.1e+3± 3e+1 nM |
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| Citation |  Emert-Sedlak, L; Kodama, T; Lerner, EC; Dai, W; Foster, C; Day, BW; Lazo, JS; Smithgall, TE Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS Chem Biol4:939-47 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein Nef/Tyrosine-protein kinase HCK |
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| Name: | Protein Nef/Tyrosine-protein kinase HCK |
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| Synonyms: | Tryrosine-Protein Kinase (HCK) + Protein Nef (NEF) |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tyrosine-protein kinase HCK |
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| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59600.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08631 |
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| Residue: | 526 |
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| Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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| Component 2 |
| Name: | Protein Nef |
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| Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef |
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| Type: | C-terminal core protein |
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| Mol. Mass.: | 23340.47 |
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| Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) |
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| Description: | P03406 |
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| Residue: | 206 |
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| Sequence: | MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
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| BDBM14807 |
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| n/a |
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| Name | BDBM14807 |
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| Synonyms: | 3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-propan-1-ol | 3-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)propan-1-ol | DFP-4AP | furanopyrimidine compound 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O2 |
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| Mol. Mass. | 345.3945 |
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| SMILES | OCCCNc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1 |
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| Structure | 
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