| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [866-1154] |
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| Ligand | BDBM264194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK Enzymatic Assay |
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| pH | 7.3±n/a |
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| IC50 | 7.00±n/a nM |
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| Comments | extracted |
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| Citation |  Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [866-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [866-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
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| Type: | Protein |
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| Mol. Mass.: | 33185.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[866-1154] |
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| Residue: | 289 |
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| Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM264194 |
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| n/a |
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| Name | BDBM264194 |
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| Synonyms: | (2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-yl) amino]-5-methylpyrimidin- 4-yl}-1H-indol-7- yl)propanamide | US10167276, Example 15 | US10654835, Example 15 | US11247983, Example 15 | US9714236, 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35N9O3 |
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| Mol. Mass. | 533.6253 |
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| SMILES | COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12 |r| |
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| Structure | 
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