| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphotransferase |
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| Ligand | BDBM43831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 298.15±0 K |
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| Ki | 1.14e+5± 4e+3 nM |
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| IC50 | 1800000±0.0 nM |
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| Citation |  Willson, M; Sanejouand, YH; Perie, J; Hannaert, V; Opperdoes, F Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase. Chem Biol9:839-47 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Phosphotransferase |
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| Name: | Phosphotransferase |
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| Synonyms: | Hexokinase |
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| Type: | Protein |
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| Mol. Mass.: | 51306.14 |
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| Organism: | Trypanosoma brucei |
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| Description: | Q38C42 |
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| Residue: | 471 |
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| Sequence: | MSRRLNNILEHISIQGNDGETVRAVKRDVAMAALTNQFTMSVESMRQIMTYLLYEMVEGL
EGRESTVRMLPSYVYKADPKRATGVFYALDLGGTNFRVLRVACKEGAVVDSSTSAFKIPK
YALEGNATDLFGFIASNVKKTMETRAPEDLNRTVPLGFTFSFPVEQTKVNRGVLIRWTKG
FSTKGVQGNDVIALLQAAFGRVSLKVNVVALCNDTVGTLISHYFKDPEVQVGVIIGTGSN
ACYFETASAVTKDPAVAARGSALTPINMESGNFDSKYRFVLPTTKFDLDIDDASLNKGQQ
ALEKMISGMYLGEIARRVIVHLSSINCLPAALQTALGNRGSFESRFAGMISADRMPGLQF
TRSTIQKVCGVDVQSIEDLRIIRDVCRLVRGRAAQLSASFCCAPLVKTQTQGRATIAIDG
SVFEKIPSFRRVLQDNINRILGPECDVRAVLAKDGSGIGAAFISAMVVNDK
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| BDBM43831 |
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| n/a |
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| Name | BDBM43831 |
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| Synonyms: | 5-(4-fluorobenzyl)-4-keto-6,7-dihydropyrazolo[1,5-a]pyrazine-2-carboxylic acid methyl ester | 5-[(4-fluorophenyl)methyl]-4-oxo-6,7-dihydropyrazolo[1,5-a]pyrazine-2-carboxylic acid methyl ester | Glucosamine derivative, 4 | MLS000326913 | SMR000179467 | cid_1475682 | methyl 5-(4-fluorobenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate | methyl 5-[(4-fluorophenyl)methyl]-4-oxidanylidene-6,7-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate | methyl 5-[(4-fluorophenyl)methyl]-4-oxo-6,7-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14FN3O3 |
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| Mol. Mass. | 303.2884 |
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| SMILES | COC(=O)c1cc2C(=O)N(Cc3ccc(F)cc3)CCn2n1 |
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| Structure | 
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