Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267474 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267474 | |||
n/a | |||
Name | BDBM267474 | ||
Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-propylpyridin-2-yl)benzamide | US9718828, Example, 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H26N6O2S | ||
Mol. Mass. | 462.567 | ||
SMILES | CCc1cnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)s1 |r,wU:18.18,wD:21.22,(1.19,10.33,;2.68,9.93,;3.07,8.44,;4.54,7.97,;4.54,6.43,;3.07,5.95,;2.68,4.46,;1.19,4.06,;.1,5.15,;.79,2.58,;1.88,1.49,;1.48,,;-.01,-.4,;-1.1,.69,;-.7,2.18,;-.41,-1.89,;.5,-3.13,;-.41,-4.38,;-.01,-5.87,;1.48,-6.26,;1.88,-7.75,;.79,-8.84,;1.19,-10.33,;-.7,-8.44,;-1.1,-6.95,;-1.87,-3.9,;-3.2,-4.67,;-4.54,-3.9,;-4.54,-2.36,;-3.2,-1.59,;-3.2,-.05,;-1.87,-2.36,;2.17,7.2,)| | ||
Structure |