Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267476 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267476 | |||
n/a | |||
Name | BDBM267476 | ||
Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-methylpyridin-2-yl)benzamide | US9718828, Example, 6 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30N6O2 | ||
Mol. Mass. | 470.5661 | ||
SMILES | CC(C)c1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H]3CC[C@H](O)CC3)n3ccnc(N)c23)c1 |r,wU:20.20,wD:23.24,(-.4,8.83,;1.08,9.23,;1.48,10.72,;2.17,8.14,;3.66,8.54,;4.75,7.45,;4.35,5.96,;2.86,5.56,;2.46,4.08,;.98,3.68,;-.11,4.77,;.58,2.19,;1.67,1.1,;1.27,-.39,;-.22,-.79,;-1.31,.3,;-.91,1.79,;-.62,-2.27,;.29,-3.52,;-.62,-4.77,;-.22,-6.25,;1.27,-6.65,;1.67,-8.14,;.58,-9.23,;.98,-10.72,;-.91,-8.83,;-1.31,-7.34,;-2.08,-4.29,;-3.42,-5.06,;-4.75,-4.29,;-4.75,-2.75,;-3.42,-1.98,;-3.42,-.44,;-2.08,-2.75,;1.77,6.65,)| | ||
Structure |