Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267478 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267478 | |||
n/a | |||
Name | BDBM267478 | ||
Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-cyclopropylpyridin-2-yl)benzamide | US9718828, Example, 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H28N6O2S | ||
Mol. Mass. | 488.605 | ||
SMILES | Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nc4CCCCc4s3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:28.32,wD:31.36,(-3.78,-.38,;-3.78,-1.92,;-5.11,-2.69,;-5.11,-4.23,;-3.78,-5,;-2.44,-4.23,;-.98,-4.7,;-.07,-3.46,;-.98,-2.21,;-.58,-.72,;.91,-.33,;1.31,1.16,;.22,2.25,;-1.27,1.85,;-1.67,.36,;.62,3.74,;-.47,4.83,;2.1,4.14,;2.5,5.62,;3.97,6.1,;3.97,7.64,;5.11,8.67,;4.79,10.18,;3.33,10.65,;2.18,9.62,;2.5,8.12,;1.6,6.87,;-2.44,-2.69,;-.58,-6.19,;.91,-6.59,;1.31,-8.08,;.22,-9.17,;.62,-10.65,;-1.27,-8.77,;-1.67,-7.28,)| | ||
Structure |