Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267485 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267485 | |||
n/a | |||
Name | BDBM267485 | ||
Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-2-fluoro-N-(4-propylpyridin-2-yl)benzamide | US9718828, Example, 14 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30N6O2S | ||
Mol. Mass. | 502.631 | ||
SMILES | CC1CCc2nc(NC(=O)c3ccc(cc3)-c3nc([C@H]4CC[C@H](O)CC4)n4ccnc(N)c34)sc2C1 |r,wU:19.19,wD:22.23,(3.01,11.41,;3.33,9.9,;4.79,9.42,;5.11,7.92,;3.97,6.89,;3.97,5.35,;2.5,4.87,;2.1,3.38,;.62,2.99,;-.47,4.07,;.22,1.5,;1.31,.41,;.91,-1.08,;-.58,-1.48,;-1.67,-.39,;-1.27,1.1,;-.98,-2.96,;-.07,-4.21,;-.98,-5.46,;-.58,-6.94,;.91,-7.34,;1.31,-8.83,;.22,-9.92,;.62,-11.41,;-1.27,-9.52,;-1.67,-8.03,;-2.44,-4.98,;-3.78,-5.75,;-5.11,-4.98,;-5.11,-3.44,;-3.78,-2.67,;-3.78,-1.13,;-2.44,-3.44,;1.6,6.12,;2.5,7.36,;2.18,8.87,)| | ||
Structure |