Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267492 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267492 | |||
n/a | |||
Name | BDBM267492 | ||
Synonyms: | 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-ethylpyridin-2-yl)benzamide | US9718828, Example, 20 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H28N6O2 | ||
Mol. Mass. | 504.5823 | ||
SMILES | Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)-c3ccccc3)c12)[C@H]1CC[C@H](O)CC1 |r,wU:31.35,wD:34.39,(-3.42,-.98,;-3.42,-2.52,;-4.75,-3.29,;-4.75,-4.83,;-3.42,-5.6,;-2.08,-4.83,;-.62,-5.31,;.29,-4.06,;-.62,-2.82,;-.22,-1.33,;1.27,-.93,;1.67,.56,;.58,1.64,;-.91,1.25,;-1.31,-.24,;.98,3.13,;-.11,4.22,;2.46,3.53,;2.86,5.02,;1.77,6.11,;2.17,7.59,;3.66,7.99,;4.75,6.9,;4.35,5.42,;1.08,8.68,;1.48,10.17,;.39,11.26,;-1.09,10.86,;-1.49,9.37,;-.4,8.29,;-2.08,-3.29,;-.22,-6.8,;1.27,-7.2,;1.67,-8.68,;.58,-9.77,;.98,-11.26,;-.91,-9.37,;-1.31,-7.89,)| | ||
Structure |