Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267511 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267511 | |||
n/a | |||
Name | BDBM267511 | ||
Synonyms: | 4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1,5-a]pyrazin-1-yl)-N-(5-ethylthiazol-2-yl)benzamide | US9718828, Example, 40 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H25F3N6O2 | ||
Mol. Mass. | 510.5109 | ||
SMILES | CO[C@H]1CC[C@H](CC1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r,wU:5.8,2.1,(-.11,-10.52,;.98,-9.43,;.58,-7.94,;-.91,-7.54,;-1.31,-6.05,;-.22,-4.96,;1.27,-5.36,;1.67,-6.85,;-.62,-3.48,;.29,-2.23,;-.62,-.99,;-.22,.5,;1.27,.9,;1.67,2.39,;.58,3.48,;-.91,3.08,;-1.31,1.59,;.98,4.96,;-.11,6.05,;2.46,5.36,;2.86,6.85,;1.77,7.94,;2.17,9.43,;3.66,9.83,;4.75,8.74,;4.35,7.25,;1.08,10.52,;-.4,10.12,;1.48,12,;.69,9.03,;-2.08,-1.46,;-3.42,-.69,;-3.42,.85,;-4.75,-1.46,;-4.75,-3,;-3.42,-3.77,;-2.08,-3,)| | ||
Structure |