Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM267513 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay A | ||
pH | 7.2±n/a | ||
Temperature | 298.15±n/a K | ||
EC50 | <10.00±n/a nM | ||
Comments | extracted | ||
Citation | De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 Publication Date 8/1/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM267513 | |||
n/a | |||
Name | BDBM267513 | ||
Synonyms: | 4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1,5-a]pyrazin-1-yl)-N-(4-cyanopyridin-2-yl)benzamide | US9718828, Example, 42 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32N6O2 | ||
Mol. Mass. | 484.5927 | ||
SMILES | CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CC[C@@H](CC3)OC)n3ccnc(N)c23)c1 |r,wU:20.20,23.27,(-1.49,10.86,;-.4,9.77,;1.08,10.17,;2.17,9.08,;3.66,9.48,;4.75,8.39,;4.35,6.9,;2.86,6.51,;2.46,5.02,;.98,4.62,;-.11,5.71,;.58,3.13,;1.67,2.04,;1.27,.56,;-.22,.16,;-1.31,1.25,;-.91,2.73,;-.62,-1.33,;.29,-2.58,;-.62,-3.82,;-.22,-5.31,;-1.31,-6.4,;-.91,-7.89,;.58,-8.29,;1.67,-7.2,;1.27,-5.71,;.98,-9.77,;-.11,-10.86,;-2.08,-3.35,;-3.42,-4.12,;-4.75,-3.35,;-4.75,-1.81,;-3.42,-1.04,;-3.42,.5,;-2.08,-1.81,;1.77,7.59,)| | ||
Structure |