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Target1-deoxy-D-xylulose 5-phosphate reductoisomerase
LigandBDBM59100
Substrate/Competitorn/a
Meas. Tech.Steady-State Inhibition Assay
pH7.4±0
Ki 202± 0 nM
Citation Sem DSBertolaet BBaker BChang ECostache ADCoutts SDong QHansen MHong VHuang XJack RMKho RLang HMa CTMeininger DPellecchia MPierre FVillar HYu L Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. Chem Biol 11:185-94 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Name:1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase
Type:Protein
Mol. Mass.:43384.52
Organism:Escherichia coli
Description:P45568
Residue:398
Sequence:
MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEA
SAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI
LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVS
ILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFC
KLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN
LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
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  Blast E-value cutoff:
BDBM59100
n/a
NameBDBM59100
Synonyms:Bi-ligand, 3
TypeSmall organic molecule
Emp. Form.C25H20N2O5S2
Mol. Mass.492.567
SMILESCc1ccc(Oc2ccc(NC(=O)CN3C(=S)S\C(=C/c4ccc(O)c(O)c4)C3=O)cc2)cc1
Structure
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