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TargetSerine/threonine-protein kinase Sgk1
LigandBDBM268875
Substrate/Competitorn/a
Meas. Tech.Enzymatic Activity Assay
pH7.4±n/a
IC50 1.10±n/a nM
Commentsextracted
Citation Nazare MHalland NSchmidt FKleemann HWeiss TSaas JStruebing C N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals US Patent  US9718825 Publication Date 8/1/2017
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Sgk1
Name:Serine/threonine-protein kinase Sgk1
Synonyms:SGK1 | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:Other Protein Type
Mol. Mass.:48954.40
Organism:Homo sapiens (Human)
Description:Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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  Blast E-value cutoff:
BDBM268875
n/a
NameBDBM268875
Synonyms:US9718825, Example 300
TypeSmall organic molecule
Emp. Form.C25H24FN7O3S
Mol. Mass.521.567
SMILESCc1n[nH]c2nc(nc(OC3CCNCC3F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
Structure
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