| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [1-999,Q252H] |
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| Ligand | BDBM50242740 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemcial Assay |
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| pH | 7.5±0 |
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| IC50 | 11±0.0 nM |
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| Citation |  Okram, B; Nagle, A; Adrián, FJ; Lee, C; Ren, P; Wang, X; Sim, T; Xie, Y; Wang, X; Xia, G; Spraggon, G; Warmuth, M; Liu, Y; Gray, NS A general strategy for creating "inactive-conformation" abl inhibitors. Chem Biol13:779-86 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosine-protein kinase ABL1 [1-999,Q252H] |
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| Name: | Tyrosine-protein kinase ABL1 [1-999,Q252H] |
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| Synonyms: | ABL | ABL1 | ABL1(Q252H) | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL (Phosphorylated) | Tyrosine-protein kinase ABL (dephosphorylated) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 108590.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_62362414 |
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| Residue: | 999 |
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| Sequence: | MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGHYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSS
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| BDBM50242740 |
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| n/a |
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| Name | BDBM50242740 |
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| Synonyms: | CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Type II inhibitor, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F3N6O2 |
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| Mol. Mass. | 456.4205 |
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| SMILES | CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C |
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| Structure | 
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