| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-hexosaminidase subunit alpha |
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| Ligand | BDBM68268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Temperature | 298.15±0 K |
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| IC50 | 1.08e+5± 5.3e+4 nM |
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| Citation |  Tropak, MB; Blanchard, JE; Withers, SG; Brown, ED; Mahuran, D High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol14:153-64 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Beta-hexosaminidase subunit alpha |
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| Name: | Beta-hexosaminidase subunit alpha |
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| Synonyms: | Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha (HexA) | HEXA | HEXA_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 60688.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06865 |
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| Residue: | 529 |
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| Sequence: | MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
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| BDBM68268 |
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| n/a |
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| Name | BDBM68268 |
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| Synonyms: | M-31862 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2O2 |
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| Mol. Mass. | 316.3532 |
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| SMILES | O=C1N(CCCc2ccccn2)C(=O)c2cccc3cccc1c23 |
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| Structure | 
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