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TargetMethionine Aminopeptidase Type 1 (MetAP1)
LigandBDBM68286
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 2.7e+3± 4e+2 nM
Citation Hu XDang YTenney KCrews PTsai CWSixt KMCole PALiu JO Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol 14:764-74 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine Aminopeptidase Type 1 (MetAP1)
Name:Aminopeptidase
Synonyms:MAP 1 | MetAP 1 | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (Human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM68286
n/a
NameBDBM68286
Synonyms:Bengamide N | Bengamide O
TypeSmall organic molecule
Emp. Form.C32H58N2O8
Mol. Mass.598.8115
SMILESCO[C@H]([C@H](O)[C@@H](O)[C@H](O)\C=C\C(C)C)C(=O)NC1CCC(CN(C)C1=O)C(=O)OCCCCCCCCCCC(C)C |r|
Structure
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