Reaction Details | |||
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Report a problem with these data | |||
Target | Apelin receptor | ||
Ligand | BDBM269666 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | [35S]GTPgammaS Binding Assay | ||
pH | 7.5±n/a | ||
EC50 | 0.068±n/a nM | ||
Comments | extracted | ||
Citation | Chen, N; Chen, X; Chen, Y; Fu, Z; Heath, JA; Horne, DB; Kaller, MR; Khakoo, AY; Kopecky, DJ; Ma, Z; Mihalic, JT; Swaminath, G; Wang, X; Yeh, W Methods of treating heart failure US Patent US10058550 Publication Date 8/28/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
| ||
BDBM269666 | |||
n/a | |||
Name | BDBM269666 | ||
Synonyms: | (2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-3-(5-methyl-2-pyrimidinyl)-2-butanesulfonamide | US10058550, Example 180.0 | US10221162, Example 180.0 | US9845310, Example 180.0 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31N7O5S | ||
Mol. Mass. | 553.633 | ||
SMILES | CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:17.18,19.20,(-8.89,-5.43,;-8.12,-4.1,;-8.89,-2.76,;-8.12,-1.43,;-8.89,-.1,;-8.12,1.24,;-6.58,1.24,;-5.81,-.1,;-6.58,-1.43,;-4.27,-.1,;-3.79,-1.56,;-2.25,-1.56,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;3.56,-1.64,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-3.02,.81,;-3.02,2.35,;-1.69,3.12,;-.36,2.35,;.98,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,)| | ||
Structure |