Ki Summary

Reaction Details

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Target

Lysine-specific histone demethylase 1A [151-852]

Ligand

BDBM103894

Substrate/Competitor

n/a

Meas. Tech.

Demethylase Biochemical Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

<50±n/a nM

Comments

extracted

Citation

Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors US Patent US9695168 Publication Date 7/4/2017

More Info.:

Get all data from this article, Assay Method

Lysine-specific histone demethylase 1A [151-852]

Name:

Lysine-specific histone demethylase 1A [151-852]

Synonyms:

AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A

Type:

n/a

Mol. Mass.:

77867.68

Organism:

Homo sapiens (Human)

Description:

ENZO (BML-SE544-0050) which consists of 151-852 aa

Residue:

702

Sequence:

LPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVF
LFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRI
KPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLG
AMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATS
YLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVN
LKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQE
LEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNG
YSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVL
KQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGE
LFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSR
WRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPAT
VHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM

BDBM103894

n/a

Name

BDBM103894

Synonyms:

US10047086, 8 | US10640503, Example 8 | US9695168, 8

Type

Small organic molecule

Emp. Form.

C26H23FN4O

Mol. Mass.

426.4854

SMILES

Cc1ccc(c(F)c1)-c1c(cc(OC[C@@H]2CCNC2)c2cncn12)-c1ccc(cc1)C#N |r,wD:14.14,(-6.52,-4.23,;-5.19,-3.46,;-5.19,-1.93,;-3.85,-1.15,;-2.52,-1.93,;-2.52,-3.46,;-1.18,-4.23,;-3.85,-4.23,;-1.18,-1.15,;-1.18,.38,;.15,1.15,;1.48,.38,;2.82,1.15,;4.15,.38,;5.48,1.15,;5.48,2.69,;6.95,3.17,;7.85,1.93,;6.95,.68,;1.48,-1.15,;2.63,-2.19,;2,-3.59,;.47,-3.43,;.15,-1.93,;-2.52,1.15,;-2.52,2.69,;-3.85,3.47,;-5.23,2.72,;-5.19,1.15,;-3.85,.38,;-6.57,3.49,;-7.9,4.26,)|

Structure