| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A [151-852] |
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| Ligand | BDBM105877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Demethylase Biochemical Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <50±n/a nM |
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| Comments | extracted |
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| Citation |  Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors US Patent US9695168 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A [151-852] |
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| Name: | Lysine-specific histone demethylase 1A [151-852] |
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| Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A |
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| Type: | n/a |
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| Mol. Mass.: | 77867.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENZO (BML-SE544-0050) which consists of 151-852 aa |
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| Residue: | 702 |
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| Sequence: | LPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVF
LFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRI
KPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLG
AMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATS
YLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVN
LKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQE
LEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNG
YSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVL
KQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGE
LFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSR
WRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPAT
VHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
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| BDBM105877 |
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| n/a |
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| Name | BDBM105877 |
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| Synonyms: | US10047086, 136 | US10640503, Example 136 | US9695168, 136 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O |
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| Mol. Mass. | 478.5881 |
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| SMILES | CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc3CC(O)Cc3c2)n2cncc12 |
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| Structure | 
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