Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 | ||
Ligand | BDBM270861 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | JAK Enzyme Assay | ||
IC50 | >10000±n/a nM | ||
Citation | Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Compounds US Patent US10059709 Publication Date 8/28/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
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BDBM270861 | |||
n/a | |||
Name | BDBM270861 | ||
Synonyms: | US10059709, 7 | ||
Type | Small organic molecule | ||
Emp. Form. | C13H22BrN5O2S | ||
Mol. Mass. | 392.315 | ||
SMILES | CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)| | ||
Structure |