Reaction Details |
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Target | Methionine aminopeptidase 2 |
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Ligand | BDBM50194621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibiton Assay |
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IC50 | >5.00e+5±n/a nM |
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Citation | Chen, X; Xie, S; Bhat, S; Kumar, N; Shapiro, TA; Liu, JO Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol16:193-202 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine aminopeptidase 2 |
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Name: | Methionine aminopeptidase 2 |
Synonyms: | MetAP2 | Methionine aminopeptidase (MetAP2) |
Type: | Protein |
Mol. Mass.: | 40537.47 |
Organism: | Plasmodium falciparum |
Description: | Q8TA23 |
Residue: | 354 |
Sequence: | MIYGKDGKYPVGEILEYNNYNLSGQSLVEKKEREKLSIDYYEDLRKAAECHRQVRKHMQA
FIKPGKKMIDIAQETERKTKELILAEKLKCGWGFPTGCSLNHCAAHYTPNYGDETVLKYD
DVCKLDFGVHVNGYIIDCAFTIAFNEKYDNLIKATQDGTNTGIKEAGIDARMCDIGEAIQ
EAIESYEIELNQKIYPIKAISNLRGHSINKYIIHGGKCVPIVRQKEKNEIMEEGELFAIE
TFASTGKGYVNHENECSHYMRNPEKQFVPIRLNSAKTLLKVINDNFDTLPFCNRWLDDLG
QTRHFMALKTLIDLNIVEPYPPLCDIKNSFTSQMEHTILLRPTCKEVLSRGPDF
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BDBM50194621 |
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n/a |
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Name | BDBM50194621 |
Synonyms: | 6S-(1'R,2'R-1',5'-dimethyl-1',2'-oxiranyl-4'-hexenyl)-5S-methoxy-4-oxobicyclo[3.1.0]hexane-1R-carbaldehyde | CHEMBL215931 | Fumarranol Analog, 7 |
Type | Small organic molecule |
Emp. Form. | C16H22O4 |
Mol. Mass. | 278.3435 |
SMILES | [#6]-[#8][C@@]12[#6]([C@@]3([#6])[#8]-[#6@@H]3-[#6]\[#6]=[#6](\[#6])-[#6])[C@@]1([#6]-[#6]-[#6]2=O)[#6]=O |
Structure |
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