Reaction Details |
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Target | Hypoxia-inducible factor 1-alpha |
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Ligand | BDBM66087 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 4.5e+3± 5e+2 nM |
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Citation | Smirnova, NA; Rakhman, I; Moroz, N; Basso, M; Payappilly, J; Kazakov, S; Hernandez-Guzman, F; Gaisina, IN; Kozikowski, AP; Ratan, RR; Gazaryan, IG Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol17:380-91 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxia-inducible factor 1-alpha |
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Name: | Hypoxia-inducible factor 1-alpha |
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
Type: | Protein |
Mol. Mass.: | 92647.24 |
Organism: | Homo sapiens (Human) |
Description: | Q16665 |
Residue: | 826 |
Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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BDBM66087 |
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n/a |
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Name | BDBM66087 |
Synonyms: | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one | 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one | Ciclopirox | Ciclopirox ethanolamine | MLS002153867 | SMR001233223 | cid_38911 |
Type | Small organic molecule |
Emp. Form. | C12H17NO2 |
Mol. Mass. | 207.2689 |
SMILES | Cc1cc(C2CCCCC2)n(O)c(=O)c1 |
Structure |
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