Found 64 hits with Last Name = 'moroz' and Initial = 'n' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81383
(Oxyquinoline, D2, #8)Show InChI InChI=1S/C21H16ClN3O2/c22-15-8-5-14(6-9-15)18(25-21-17(26)4-2-12-24-21)16-10-7-13-3-1-11-23-19(13)20(16)27/h1-12,18,26-27H,(H,24,25) | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81388
(Oxyquinoline, D3, #4)Show SMILES COc1ccc(cc1OC)C(NC(=O)CC(C)C)c1ccc2cccnc2c1O Show InChI InChI=1S/C23H26N2O4/c1-14(2)12-20(26)25-21(16-8-10-18(28-3)19(13-16)29-4)17-9-7-15-6-5-11-24-22(15)23(17)27/h5-11,13-14,21,27H,12H2,1-4H3,(H,25,26) | PDB
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PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81389
(Oxyquinoline, D3, #7)Show SMILES COc1ccc(cc1OC)C(NC(=O)Cc1ccccc1)c1ccc2cccnc2c1O Show InChI InChI=1S/C26H24N2O4/c1-31-21-13-11-19(16-22(21)32-2)24(28-23(29)15-17-7-4-3-5-8-17)20-12-10-18-9-6-14-27-25(18)26(20)30/h3-14,16,24,30H,15H2,1-2H3,(H,28,29) | PDB
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| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81387
(Oxyquinoline, D3, #1 | cid_3129250)Show SMILES CCCCC(=O)NC(c1ccc(OC)c(OC)c1)c1ccc2cccnc2c1O Show InChI InChI=1S/C23H26N2O4/c1-4-5-8-20(26)25-21(16-10-12-18(28-2)19(14-16)29-3)17-11-9-15-7-6-13-24-22(15)23(17)27/h6-7,9-14,21,27H,4-5,8H2,1-3H3,(H,25,26) | PDB
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| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81390
(Oxyquinoline, D3, #6)Show SMILES CCCCC(=O)NC(c1cccc(c1)N(=O)=O)c1ccc2cccnc2c1O Show InChI InChI=1S/C21H21N3O4/c1-2-3-9-18(25)23-19(15-6-4-8-16(13-15)24(27)28)17-11-10-14-7-5-12-22-20(14)21(17)26/h4-8,10-13,19,26H,2-3,9H2,1H3,(H,23,25) | PDB
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| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81382
(Oxyquinoline, D2, #12)Show InChI InChI=1S/C22H20N4O/c1-14-6-5-8-19(24-14)26-21(18-7-3-4-13-23-18)17-12-11-16-10-9-15(2)25-20(16)22(17)27/h3-13,21,27H,1-2H3,(H,24,26) | PDB
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| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM66087
(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)Show InChI InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3 | PDB
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| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM52237
(2-methyl-7-[phenyl-(2-pyridinylamino)methyl]-8-qui...)Show InChI InChI=1S/C22H19N3O/c1-15-10-11-17-12-13-18(22(26)21(17)24-15)20(16-7-3-2-4-8-16)25-19-9-5-6-14-23-19/h2-14,20,26H,1H3,(H,23,25) | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81385
(Oxyquinoline, D2, #13)Show SMILES Cc1ccnc(NC(c2ccc3OCOc3c2)c2ccc3cccnc3c2O)c1 Show InChI InChI=1S/C23H19N3O3/c1-14-8-10-24-20(11-14)26-21(16-5-7-18-19(12-16)29-13-28-18)17-6-4-15-3-2-9-25-22(15)23(17)27/h2-12,21,27H,13H2,1H3,(H,24,26) | PDB
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PC sid
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81380
(Oxyquinoline, D1, #10)Show InChI InChI=1S/C20H21N3O/c24-20-17(7-6-15-5-4-10-22-18(15)20)19(16-8-11-21-12-9-16)23-13-2-1-3-14-23/h4-12,19,24H,1-3,13-14H2 | PDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81381
(Oxyquinoline, D2, #9)Show InChI InChI=1S/C21H18N4O/c1-14-7-8-15-9-10-17(21(26)20(15)24-14)19(16-5-4-11-22-13-16)25-18-6-2-3-12-23-18/h2-13,19,26H,1H3,(H,23,25) | PDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81391
(Oxyquinoline, D3, #11)Show SMILES CCC(=O)NC(c1ccc2OCOc2c1)c1cc(c2cccnc2c1O)N(=O)=O Show InChI InChI=1S/C20H17N3O6/c1-2-17(24)22-18(11-5-6-15-16(8-11)29-10-28-15)13-9-14(23(26)27)12-4-3-7-21-19(12)20(13)25/h3-9,18,25H,2,10H2,1H3,(H,22,24) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81384
(Oxyquinoline, D2, #3)Show SMILES COc1ccc(cc1OC)C(Nc1ccccn1)c1ccc2ccc(C)nc2c1O Show InChI InChI=1S/C24H23N3O3/c1-15-7-8-16-9-11-18(24(28)23(16)26-15)22(27-21-6-4-5-13-25-21)17-10-12-19(29-2)20(14-17)30-3/h4-14,22,28H,1-3H3,(H,25,27) | PDB
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PC sid
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM81386
(Oxyquinoline, D2, #2)Show SMILES Cc1cccc(NC(c2ccc3OCOc3c2)c2ccc3ccc(C)nc3c2O)n1 Show InChI InChI=1S/C24H21N3O3/c1-14-4-3-5-21(25-14)27-22(17-9-11-19-20(12-17)30-13-29-19)18-10-8-16-7-6-15(2)26-23(16)24(18)28/h3-12,22,28H,13H2,1-2H3,(H,25,27) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Weill Medical College of Cornell University
| Assay Description
The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral... |
Chem Biol 17: 380-91 (2010)
Article DOI: 10.1016/j.chembiol.2010.03.008
BindingDB Entry DOI: 10.7270/Q20K271K |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452465
(CHEMBL4209251)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,18.19,wD:7.6,(75.48,-29.25,;74.16,-28.48,;74.17,-26.95,;72.83,-29.24,;71.5,-28.47,;71.51,-26.94,;70.17,-29.23,;68.84,-28.45,;68.85,-26.91,;67.52,-26.13,;66.19,-26.89,;66.18,-28.43,;67.51,-29.21,;64.86,-26.12,;64.86,-24.58,;66.2,-23.81,;66.21,-22.27,;67.55,-21.51,;68.86,-22.28,;68.85,-23.8,;70.19,-21.53,;71.51,-22.3,;64.88,-21.5,;63.54,-22.26,;62.21,-21.49,;60.87,-22.25,;60.86,-23.79,;62.2,-24.57,;63.54,-23.8,;59.53,-24.55,;59.52,-26.09,;58.18,-26.85,;56.85,-26.08,;56.86,-24.54,;55.54,-23.77,;58.2,-23.77,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22-/m1/s1 | PDB
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| PC cid
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| n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452466
(CHEMBL4205825)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(45.91,-35.08,;45.92,-33.55,;47.24,-32.8,;48.56,-33.58,;44.6,-32.79,;43.27,-33.55,;43.26,-35.09,;41.92,-35.85,;41.91,-37.39,;43.24,-38.17,;44.58,-37.41,;45.91,-38.18,;45.9,-39.72,;44.56,-40.49,;43.23,-39.71,;47.23,-40.5,;48.56,-39.74,;48.57,-38.22,;49.88,-40.52,;50.26,-41.99,;51.74,-41.61,;53.06,-42.38,;51.35,-40.13,;40.59,-35.07,;39.26,-35.84,;37.92,-35.06,;37.93,-33.52,;39.27,-32.76,;40.6,-33.53,;41.94,-32.77,;36.58,-35.83,;36.57,-37.37,;35.24,-38.13,;33.91,-37.35,;33.92,-35.81,;32.59,-35.04,;35.25,-35.05,)| Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
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| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452467
(CHEMBL4218032)Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)| Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452451
(CHEMBL4210772)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)(C)CO)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;19.63,-10.35,;21.17,-10.35,;21.73,-12.46,;23.06,-11.7,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O3/c1-17(15-36)30-26-33-24-12-7-19(18-5-4-6-20(29)13-18)14-23(24)25(34-26)31-21-8-10-22(11-9-21)32-27(38)35-28(2,3)16-37/h4-7,12-14,17,21-22,36-37H,8-11,15-16H2,1-3H3,(H2,32,35,38)(H2,30,31,33,34)/t17-,21-,22+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452455
(CHEMBL4215510)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(cnc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(16.43,-4.72,;15.1,-5.48,;15.1,-7.02,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O2/c1-16(2)24(15-37)34-28(38)33-22-10-8-21(9-11-22)32-26-23-13-19(18-6-5-7-20(29)12-18)14-30-25(23)35-27(36-26)31-17(3)4/h5-7,12-14,16-17,21-22,24,37H,8-11,15H2,1-4H3,(H2,33,34,38)(H2,30,31,32,35,36)/t21-,22+,24-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452468
(CHEMBL4205090)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452457
(CHEMBL4213559)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 71 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452458
(CHEMBL4207138)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2(CO)CCCC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.02,;15.11,-5.48,;16.44,-4.72,;17.76,-5.49,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;21.63,-10.74,;21.11,-9.29,;19.58,-9.33,;19.14,-10.81,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H39FN6O3/c1-19(17-38)32-28-35-26-12-7-21(20-5-4-6-22(31)15-20)16-25(26)27(36-28)33-23-8-10-24(11-9-23)34-29(40)37-30(18-39)13-2-3-14-30/h4-7,12,15-16,19,23-24,38-39H,2-3,8-11,13-14,17-18H2,1H3,(H2,34,37,40)(H2,32,33,35,36)/t19-,23-,24+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 78 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452460
(CHEMBL4218972)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(nc2ccc(cc12)-c1cccc(F)c1)N(C)CCO |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,;13.79,-4.72,;13.8,-3.18,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)29-27(36)31-22-10-8-21(9-11-22)30-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)32-26(33-25)34(3)13-14-35/h4-7,12,15-17,21-22,35H,8-11,13-14H2,1-3H3,(H2,29,31,36)(H,30,32,33)/t21-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452461
(CHEMBL4214047)Show SMILES COCCNc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-17(2)30-27(35)32-22-10-8-21(9-11-22)31-25-23-16-19(18-5-4-6-20(28)15-18)7-12-24(23)33-26(34-25)29-13-14-36-3/h4-7,12,15-17,21-22H,8-11,13-14H2,1-3H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 380 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452462
(CHEMBL4217505)Show SMILES COC[C@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,wD:3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 850 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452469
(CHEMBL4210169)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452470
(CHEMBL4207573)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H33FN6O2/c1-16(15-35)29-26-33-24-12-5-18(17-3-2-4-19(28)13-17)14-23(24)25(34-26)30-20-6-8-21(9-7-20)31-27(36)32-22-10-11-22/h2-5,12-14,16,20-22,35H,6-11,15H2,1H3,(H2,31,32,36)(H2,29,30,33,34)/t16-,20-,21+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452465
(CHEMBL4209251)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,18.19,wD:7.6,(75.48,-29.25,;74.16,-28.48,;74.17,-26.95,;72.83,-29.24,;71.5,-28.47,;71.51,-26.94,;70.17,-29.23,;68.84,-28.45,;68.85,-26.91,;67.52,-26.13,;66.19,-26.89,;66.18,-28.43,;67.51,-29.21,;64.86,-26.12,;64.86,-24.58,;66.2,-23.81,;66.21,-22.27,;67.55,-21.51,;68.86,-22.28,;68.85,-23.8,;70.19,-21.53,;71.51,-22.3,;64.88,-21.5,;63.54,-22.26,;62.21,-21.49,;60.87,-22.25,;60.86,-23.79,;62.2,-24.57,;63.54,-23.8,;59.53,-24.55,;59.52,-26.09,;58.18,-26.85,;56.85,-26.08,;56.86,-24.54,;55.54,-23.77,;58.2,-23.77,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 460 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452466
(CHEMBL4205825)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(45.91,-35.08,;45.92,-33.55,;47.24,-32.8,;48.56,-33.58,;44.6,-32.79,;43.27,-33.55,;43.26,-35.09,;41.92,-35.85,;41.91,-37.39,;43.24,-38.17,;44.58,-37.41,;45.91,-38.18,;45.9,-39.72,;44.56,-40.49,;43.23,-39.71,;47.23,-40.5,;48.56,-39.74,;48.57,-38.22,;49.88,-40.52,;50.26,-41.99,;51.74,-41.61,;53.06,-42.38,;51.35,-40.13,;40.59,-35.07,;39.26,-35.84,;37.92,-35.06,;37.93,-33.52,;39.27,-32.76,;40.6,-33.53,;41.94,-32.77,;36.58,-35.83,;36.57,-37.37,;35.24,-38.13,;33.91,-37.35,;33.92,-35.81,;32.59,-35.04,;35.25,-35.05,)| Show InChI InChI=1S/C28H34FN5O3/c1-16(15-35)30-28-33-25-10-5-18(17-3-2-4-20(29)11-17)14-24(25)26(34-28)31-21-6-8-22(9-7-21)32-27(37)19-12-23(36)13-19/h2-5,10-11,14,16,19,21-23,35-36H,6-9,12-13,15H2,1H3,(H,32,37)(H2,30,31,33,34)/t16-,19-,21-,22-,23-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 470 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452471
(CHEMBL4214562)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N(C)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;19.06,-13.98,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O/c1-17(2)30-27-33-25-14-9-20(19-7-6-8-21(29)15-19)16-24(25)26(34-27)31-22-10-12-23(13-11-22)32-28(36)35(5)18(3)4/h6-9,14-18,22-23H,10-13H2,1-5H3,(H,32,36)(H2,30,31,33,34)/t22-,23+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452467
(CHEMBL4218032)Show SMILES CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)| Show InChI InChI=1S/C31H42N6O2/c1-19(2)32-26-15-23(16-26)30(39)35-25-12-10-24(11-13-25)34-29-27-17-22(21-7-5-4-6-8-21)9-14-28(27)36-31(37-29)33-20(3)18-38/h4-9,14,17,19-20,23-26,32,38H,10-13,15-16,18H2,1-3H3,(H,35,39)(H2,33,34,36,37)/t20-,23-,24-,25-,26-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452472
(CHEMBL4212627)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2nc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.09,-4.73,;17.76,-5.49,;16.43,-4.72,;15.1,-5.48,;15.1,-7.02,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.45,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H36FN7O2/c1-16(2)29-27(36)32-21-10-8-20(9-11-21)31-25-24-23(34-26(35-25)30-17(3)15-37-4)13-12-22(33-24)18-6-5-7-19(28)14-18/h5-7,12-14,16-17,20-21H,8-11,15H2,1-4H3,(H2,29,32,36)(H2,30,31,34,35)/t17-,20-,21+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452472
(CHEMBL4212627)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2nc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.09,-4.73,;17.76,-5.49,;16.43,-4.72,;15.1,-5.48,;15.1,-7.02,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.45,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H36FN7O2/c1-16(2)29-27(36)32-21-10-8-20(9-11-21)31-25-24-23(34-26(35-25)30-17(3)15-37-4)13-12-22(33-24)18-6-5-7-19(28)14-18/h5-7,12-14,16-17,20-21H,8-11,15H2,1-4H3,(H2,29,32,36)(H2,30,31,34,35)/t17-,20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452468
(CHEMBL4205090)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452471
(CHEMBL4214562)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N(C)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;19.06,-13.98,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O/c1-17(2)30-27-33-25-14-9-20(19-7-6-8-21(29)15-19)16-24(25)26(34-27)31-22-10-12-23(13-11-22)32-28(36)35(5)18(3)4/h6-9,14-18,22-23H,10-13H2,1-5H3,(H,32,36)(H2,30,31,33,34)/t22-,23+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452473
(CHEMBL4205804)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O2/c1-17(2)30-28(36)33-23-11-9-22(10-12-23)32-26-24-15-20(19-6-5-7-21(29)14-19)8-13-25(24)34-27(35-26)31-18(3)16-37-4/h5-8,13-15,17-18,22-23H,9-12,16H2,1-4H3,(H2,30,33,36)(H2,31,32,34,35)/t18-,22-,23+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452470
(CHEMBL4207573)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H33FN6O2/c1-16(15-35)29-26-33-24-12-5-18(17-3-2-4-19(28)13-17)14-23(24)25(34-26)30-20-6-8-21(9-7-20)31-27(36)32-22-10-11-22/h2-5,12-14,16,20-22,35H,6-11,15H2,1H3,(H2,31,32,36)(H2,29,30,33,34)/t16-,20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452474
(CHEMBL4217523)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)| Show InChI InChI=1S/C28H35N5O3/c1-17(16-34)29-28-32-25-12-7-19(18-5-3-2-4-6-18)15-24(25)26(33-28)30-21-8-10-22(11-9-21)31-27(36)20-13-23(35)14-20/h2-7,12,15,17,20-23,34-35H,8-11,13-14,16H2,1H3,(H,31,36)(H2,29,30,32,33)/t17-,20-,21-,22-,23-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452456
(CHEMBL4206652)Show SMILES CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ncc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H38FN7O3/c1-16(2)24(15-38)34-28(39)33-22-9-7-21(8-10-22)32-26-23-12-19(18-5-4-6-20(29)11-18)13-30-25(23)35-27(36-26)31-17(3)14-37/h4-6,11-13,16-17,21-22,24,37-38H,7-10,14-15H2,1-3H3,(H2,33,34,39)(H2,30,31,32,35,36)/t17-,21-,22+,24+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452475
(CHEMBL4218179)Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452473
(CHEMBL4205804)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.73,-12.46,;20.41,-10.15,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H37FN6O2/c1-17(2)30-28(36)33-23-11-9-22(10-12-23)32-26-24-15-20(19-6-5-7-21(29)14-19)8-13-25(24)34-27(35-26)31-18(3)16-37-4/h5-8,13-15,17-18,22-23H,9-12,16H2,1-4H3,(H2,30,33,36)(H2,31,32,34,35)/t18-,22-,23+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452464
(CHEMBL4212125)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,7.6,18.19,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;13.79,-4.72,;15.1,-5.48,;15.1,-7.01,;16.43,-4.73,;17.75,-5.51,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.77,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452474
(CHEMBL4217523)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)| Show InChI InChI=1S/C28H35N5O3/c1-17(16-34)29-28-32-25-12-7-19(18-5-3-2-4-6-18)15-24(25)26(33-28)30-21-8-10-22(11-9-21)31-27(36)20-13-23(35)14-20/h2-7,12,15,17,20-23,34-35H,8-11,13-14,16H2,1H3,(H,31,36)(H2,29,30,32,33)/t17-,20-,21-,22-,23-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452463
(CHEMBL4206328)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.11,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.4,-11.69,;20.41,-10.15,;21.75,-9.4,;23.07,-10.18,;23.06,-11.71,;24.38,-12.49,;21.73,-12.46,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H40FN7O2/c1-19(18-39)32-29-36-27-13-8-21(20-5-3-6-22(31)15-20)16-26(27)28(37-29)33-23-9-11-24(12-10-23)34-30(40)35-25-7-4-14-38(2)17-25/h3,5-6,8,13,15-16,19,23-25,39H,4,7,9-12,14,17-18H2,1-2H3,(H2,34,35,40)(H2,32,33,36,37)/t19-,23-,24+,25?/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452475
(CHEMBL4218179)Show SMILES CC(C)[C@@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O3/c1-17(2)26(16-38)35-29(39)33-23-10-8-22(9-11-23)32-27-24-14-20(19-5-4-6-21(30)13-19)7-12-25(24)34-28(36-27)31-18(3)15-37/h4-7,12-14,17-18,22-23,26,37-38H,8-11,15-16H2,1-3H3,(H2,33,35,39)(H2,31,32,34,36)/t18-,22-,23+,26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452469
(CHEMBL4210169)Show SMILES COC[C@@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C28H35FN6O2/c1-17(16-37-2)30-27-34-25-13-6-19(18-4-3-5-20(29)14-18)15-24(25)26(35-27)31-21-7-9-22(10-8-21)32-28(36)33-23-11-12-23/h3-6,13-15,17,21-23H,7-12,16H2,1-2H3,(H2,32,33,36)(H2,30,31,34,35)/t17-,21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 270 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452476
(CHEMBL4206902)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO |r| Show InChI InChI=1S/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)/t64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85+,86-,87-,88-,89-,90-,99-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452459
(CHEMBL4209646)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(NC(C)C)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,7.6,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;13.79,-4.72,;15.1,-5.48,;15.1,-7.02,;16.43,-4.72,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O/c1-16(2)29-26-33-24-13-8-19(18-6-5-7-20(28)14-18)15-23(24)25(34-26)31-21-9-11-22(12-10-21)32-27(35)30-17(3)4/h5-8,13-17,21-22H,9-12H2,1-4H3,(H2,30,32,35)(H2,29,31,33,34)/t21-,22+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452452
(CHEMBL4204379)Show SMILES C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)N2CC(O)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,1.0,wD:12.15,(67.01,-7.35,;67.02,-5.82,;68.34,-5.07,;69.66,-5.85,;65.7,-5.06,;64.37,-5.82,;64.36,-7.36,;63.02,-8.12,;63.01,-9.66,;64.34,-10.44,;65.68,-9.68,;67.01,-10.45,;67,-11.99,;65.66,-12.76,;64.33,-11.98,;68.33,-12.77,;69.66,-12.01,;69.67,-10.49,;70.98,-12.78,;71.36,-14.26,;72.84,-13.88,;74.16,-14.65,;72.45,-12.4,;61.69,-7.34,;60.36,-8.11,;59.02,-7.33,;59.03,-5.79,;60.37,-5.03,;61.7,-5.8,;63.04,-5.04,;57.68,-8.1,;57.68,-9.64,;56.34,-10.4,;55.01,-9.62,;55.02,-8.08,;53.69,-7.31,;56.35,-7.32,)| Show InChI InChI=1S/C27H33FN6O3/c1-16(15-35)29-26-32-24-10-5-18(17-3-2-4-19(28)11-17)12-23(24)25(33-26)30-20-6-8-21(9-7-20)31-27(37)34-13-22(36)14-34/h2-5,10-12,16,20-22,35-36H,6-9,13-15H2,1H3,(H,31,37)(H2,29,30,32,33)/t16-,20-,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 420 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452464
(CHEMBL4212125)Show SMILES CC(C)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,7.6,18.19,(21.73,-12.46,;20.4,-11.68,;20.41,-10.15,;19.07,-12.44,;17.75,-11.67,;17.75,-10.15,;16.41,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.44,-7.02,;12.45,-5.48,;13.79,-4.72,;15.1,-5.48,;15.1,-7.01,;16.43,-4.73,;17.75,-5.51,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.77,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C27H35FN6O2/c1-16(2)29-27(36)32-22-10-8-21(9-11-22)31-25-23-14-19(18-5-4-6-20(28)13-18)7-12-24(23)33-26(34-25)30-17(3)15-35/h4-7,12-14,16-17,21-22,35H,8-11,15H2,1-3H3,(H2,29,32,36)(H2,30,31,33,34)/t17-,21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 74 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
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