Ki Summary

Reaction Details

Report a problem with these data

Target

Atrial natriuretic peptide receptor 1

Ligand

BDBM50452467

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1747591 (CHEMBL4182101)

EC50

320±n/a nM

Citation

Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem25:6680-6694 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Atrial natriuretic peptide receptor 1

Name:

Atrial natriuretic peptide receptor 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

118919.35

Organism:

Homo sapiens (Human)

Description:

ChEMBL_700223

Residue:

1061

Sequence:

MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG

BDBM50452467

n/a

Name

BDBM50452467

Synonyms:

CHEMBL4218032

Type

Small organic molecule

Emp. Form.

C31H42N6O2

Mol. Mass.

530.7042

SMILES

CC(C)N[C@H]1C[C@@H](C1)C(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1ccccc1 |r,wU:14.18,22.24,4.3,wD:11.11,6.8,(53.52,-15.72,;52.19,-14.94,;52.21,-13.41,;50.86,-15.7,;49.53,-14.92,;48.05,-15.31,;47.67,-13.83,;49.15,-13.44,;46.35,-13.06,;46.36,-11.53,;45.02,-13.82,;43.69,-13.04,;43.69,-11.49,;42.36,-10.72,;41.02,-11.48,;41.02,-13.02,;42.35,-13.8,;39.69,-10.71,;39.7,-9.16,;41.04,-8.39,;41.05,-6.85,;42.39,-6.09,;43.71,-6.86,;43.7,-8.39,;45.03,-6.1,;46.36,-6.88,;39.72,-6.08,;38.38,-6.84,;37.05,-6.06,;35.7,-6.82,;35.69,-8.37,;37.03,-9.15,;38.37,-8.38,;34.35,-9.14,;34.35,-10.68,;33.01,-11.44,;31.68,-10.66,;31.68,-9.12,;33.02,-8.35,)|

Structure