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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Atrial natriuretic peptide receptor 1 | ||
| Ligand | BDBM50452465 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1747591 (CHEMBL4182101) | ||
| EC50 | 460±n/a nM | ||
| Citation |  Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem25:6680-6694 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Atrial natriuretic peptide receptor 1 | |||
| Name: | Atrial natriuretic peptide receptor 1 | ||
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 118919.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_700223 | ||
| Residue: | 1061 | ||
| Sequence: |
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| BDBM50452465 | |||
| n/a | |||
| Name | BDBM50452465 | ||
| Synonyms: | CHEMBL4209251 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35FN6O2 | ||
| Mol. Mass. | 494.6042 | ||
| SMILES | CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,18.19,wD:7.6,(75.48,-29.25,;74.16,-28.48,;74.17,-26.95,;72.83,-29.24,;71.5,-28.47,;71.51,-26.94,;70.17,-29.23,;68.84,-28.45,;68.85,-26.91,;67.52,-26.13,;66.19,-26.89,;66.18,-28.43,;67.51,-29.21,;64.86,-26.12,;64.86,-24.58,;66.2,-23.81,;66.21,-22.27,;67.55,-21.51,;68.86,-22.28,;68.85,-23.8,;70.19,-21.53,;71.51,-22.3,;64.88,-21.5,;63.54,-22.26,;62.21,-21.49,;60.87,-22.25,;60.86,-23.79,;62.2,-24.57,;63.54,-23.8,;59.53,-24.55,;59.52,-26.09,;58.18,-26.85,;56.85,-26.08,;56.86,-24.54,;55.54,-23.77,;58.2,-23.77,)| | ||
| Structure | 
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