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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Atrial natriuretic peptide receptor 1 | ||
| Ligand | BDBM50452457 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1747591 (CHEMBL4182101) | ||
| EC50 | 71±n/a nM | ||
| Citation |  Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem25:6680-6694 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Atrial natriuretic peptide receptor 1 | |||
| Name: | Atrial natriuretic peptide receptor 1 | ||
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 118919.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_700223 | ||
| Residue: | 1061 | ||
| Sequence: |
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| BDBM50452457 | |||
| n/a | |||
| Name | BDBM50452457 | ||
| Synonyms: | CHEMBL4213559 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H39FN6O3 | ||
| Mol. Mass. | 538.6568 | ||
| SMILES | CC(C)[C@H](CO)NC(=O)N[C@H]1CC[C@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:13.16,10.9,21.22,wD:3.2,(21.75,-9.39,;20.42,-10.15,;19.1,-9.37,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;19.07,-12.44,;17.75,-11.67,;17.76,-10.15,;16.42,-12.43,;15.09,-11.65,;13.75,-12.42,;12.42,-11.64,;12.43,-10.1,;13.77,-9.34,;15.09,-10.11,;11.1,-9.32,;11.11,-7.78,;12.45,-7.02,;12.45,-5.48,;13.79,-4.72,;15.11,-5.48,;15.1,-7.02,;16.44,-4.72,;17.76,-5.49,;11.12,-4.7,;9.79,-5.46,;8.46,-4.69,;7.11,-5.45,;7.11,-6.99,;8.44,-7.77,;9.78,-7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| | ||
| Structure | 
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