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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Atrial natriuretic peptide receptor 1 | ||
| Ligand | BDBM50452470 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1747591 (CHEMBL4182101) | ||
| EC50 | 330±n/a nM | ||
| Citation |  Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem25:6680-6694 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Atrial natriuretic peptide receptor 1 | |||
| Name: | Atrial natriuretic peptide receptor 1 | ||
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 118919.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_700223 | ||
| Residue: | 1061 | ||
| Sequence: |
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| BDBM50452470 | |||
| n/a | |||
| Name | BDBM50452470 | ||
| Synonyms: | CHEMBL4207573 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H33FN6O2 | ||
| Mol. Mass. | 492.5883 | ||
| SMILES | C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.1,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| | ||
| Structure | 
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