Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Atrial natriuretic peptide receptor 1 | ||
| Ligand | BDBM50452474 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1747591 (CHEMBL4182101) | ||
| EC50 | 900±n/a nM | ||
| Citation |  Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem25:6680-6694 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Atrial natriuretic peptide receptor 1 | |||
| Name: | Atrial natriuretic peptide receptor 1 | ||
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 118919.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_700223 | ||
| Residue: | 1061 | ||
| Sequence: |
| ||
| BDBM50452474 | |||
| n/a | |||
| Name | BDBM50452474 | ||
| Synonyms: | CHEMBL4217523 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H35N5O3 | ||
| Mol. Mass. | 489.6092 | ||
| SMILES | C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)| | ||
| Structure | 
| ||