| Reaction Details |
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 | Report a problem with these data |
| Target | Sentrin-specific protease 6 |
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| Ligand | BDBM81510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorogenic Assay |
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| pH | 8±0 |
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| Temperature | 310.15±0 K |
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| IC50 | >1.00e+5±0 nM |
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| Citation |  Albrow, VE; Ponder, EL; Fasci, D; Békés, M; Deu, E; Salvesen, GS; Bogyo, M Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol18:722-32 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Sentrin-specific protease 6 |
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| Name: | Sentrin-specific protease 6 |
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| Synonyms: | KIAA0797 | SENP6 | SENP6_HUMAN | SSP1 | SUMO-1-specific protease | SUSP1 | Sentrin-specific protease 6 (SENP6) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 126147.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZR1 |
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| Residue: | 1112 |
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| Sequence: | MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDE
DSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSEN
TQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRL
QGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQ
AITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQ
TNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSAC
SSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKR
RKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHD
PVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLT
NLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYE
ESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPP
PAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQ
RERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPK
YEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSN
PGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLS
STHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQ
WHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPK
VPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQE
DQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
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| BDBM81510 |
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| n/a |
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| Name | BDBM81510 |
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| Synonyms: | JCP-666 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H36N4O9 |
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| Mol. Mass. | 764.778 |
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| SMILES | OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r| |
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| Structure | 
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