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TargetTyrosine-protein kinase transforming protein Abl
LigandBDBM3005
Substrate/Competitor[Val5]-Angiotensin II
Meas. Tech.Kinase Inhibition Assay
pH7.5±n/a
Temperature293.15±n/a K
IC50 410±n/a nM
Citation Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem40:3601-16 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Tyrosine-protein kinase transforming protein Abl
Name:Tyrosine-protein kinase transforming protein Abl
Synonyms:ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL
Type:Enzyme
Mol. Mass.:81895.89
Organism:Abelson murine leukemia virus
Description:P00521
Residue:746
Sequence:
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM3005
[Val5]-Angiotensin II
Name:[Val5]-Angiotensin II
Synonyms:n/a
Type:Peptide
Mol. Mass.:2501.86
Organism:n/a
Description:n/a
Residue:23
Sequence:
Asp-Arg-Val-Tyr-Val-His-Pro-Phe