Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase transforming protein Abl

Ligand

BDBM3011

Substrate/Competitor

n/a

Meas. Tech.

Kinase Inhibition Assay

IC50

>10000±n/a nM

Citation

Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem40:3601-16 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase transforming protein Abl

Name:

Tyrosine-protein kinase transforming protein Abl

Synonyms:

ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL

Type:

Enzyme

Mol. Mass.:

81895.89

Organism:

Abelson murine leukemia virus

Description:

P00521

Residue:

746

Sequence:

YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR

BDBM3011

n/a

Name

BDBM3011

Synonyms:

3-((4-Methoxyphenyl)-amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 12 | 4-N-(3-chlorophenyl)-3-N-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

Type

Small organic molecule

Emp. Form.

C18H15ClN6O

Mol. Mass.

366.804

SMILES

COc1ccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1

Structure