Reaction Details |
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Target | Tyrosine-protein kinase transforming protein Abl |
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Ligand | BDBM3014 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Inhibition Assay |
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IC50 | 260±n/a nM |
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Citation | Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem40:3601-16 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase transforming protein Abl |
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Name: | Tyrosine-protein kinase transforming protein Abl |
Synonyms: | ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL |
Type: | Enzyme |
Mol. Mass.: | 81895.89 |
Organism: | Abelson murine leukemia virus |
Description: | P00521 |
Residue: | 746 |
Sequence: | YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
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BDBM3014 |
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n/a |
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Name | BDBM3014 |
Synonyms: | 3-((3-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine | 3-({4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)phenol | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 15 |
Type | Small organic molecule |
Emp. Form. | C17H13ClN6O |
Mol. Mass. | 352.778 |
SMILES | Oc1cccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1 |
Structure |
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