| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase transforming protein Abl |
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| Ligand | BDBM3022 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assay |
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| IC50 | 3760±n/a nM |
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| Citation |  Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem40:3601-16 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase transforming protein Abl |
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| Name: | Tyrosine-protein kinase transforming protein Abl |
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| Synonyms: | ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL |
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| Type: | Enzyme |
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| Mol. Mass.: | 81895.89 |
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| Organism: | Abelson murine leukemia virus |
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| Description: | P00521 |
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| Residue: | 746 |
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| Sequence: | YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
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| BDBM3022 |
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| n/a |
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| Name | BDBM3022 |
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| Synonyms: | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 23 | N-(3-chlorophenyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClN5 |
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| Mol. Mass. | 321.764 |
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| SMILES | Clc1cccc(Nc2ncnc3n[nH]c(-c4ccccc4)c23)c1 |
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| Structure | 
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