| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase transforming protein Abl |
|---|
| Ligand | BDBM3023 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Inhibition Assay |
|---|
| IC50 | 180±n/a nM |
|---|
| Citation |  Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem40:3601-16 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase transforming protein Abl |
|---|
| Name: | Tyrosine-protein kinase transforming protein Abl |
|---|
| Synonyms: | ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 81895.89 |
|---|
| Organism: | Abelson murine leukemia virus |
|---|
| Description: | P00521 |
|---|
| Residue: | 746 |
|---|
| Sequence: | YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
|
|
|
|---|
| BDBM3023 |
|---|
| n/a |
|---|
| Name | BDBM3023 |
|---|
| Synonyms: | 3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}phenol | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 24 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12ClN5O |
|---|
| Mol. Mass. | 337.763 |
|---|
| SMILES | Oc1cccc(c1)-c1[nH]nc2ncnc(Nc3cccc(Cl)c3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
