Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM84533 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Assay |
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pH | 7.5±0 |
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Temperature | 303.15±0 K |
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IC50 | 0.8±0.0 nM |
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Citation | Kunick, C; Zeng, Z; Gussio, R; Zaharevitz, D; Leost, M; Totzke, F; Schächtele, C; Kubbutat, MH; Meijer, L; Lemcke, T Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem6:541-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM84533 |
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n/a |
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Name | BDBM84533 |
Synonyms: | Alsterpaullone derivative, 7 | BDBM50375663 |
Type | Small organic molecule |
Emp. Form. | C19H14N4O3 |
Mol. Mass. | 346.3395 |
SMILES | [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccc(CCC#N)cc-34)c2c1 |
Structure |
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