| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase 2 |
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| Ligand | BDBM50078117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Ki | 36±0.0 nM |
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| Citation |  Kuntz, DA; Zhong, W; Guo, J; Rose, DR; Boons, GJ The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem10:268-77 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-mannosidase 2 |
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| Name: | Alpha-mannosidase 2 |
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| Synonyms: | Alpha-mannosidase 2 | GmII | Golgi alpha-mannosidase II | MAN2_DROME | alpha-Man-IIa |
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| Type: | Protein |
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| Mol. Mass.: | 126735.79 |
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| Organism: | Drosophila melanogaster (Fruit fly) |
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| Description: | Q24451 |
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| Residue: | 1108 |
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| Sequence: | MLRIRRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGE
EMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDI
DGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRH
LHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRN
VLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKEL
AQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSC
PWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNY
ERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSG
YYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGT
AKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVE
DSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWS
WHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPT
SLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGV
RSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIR
NLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFI
EDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLE
KVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDL
DVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFL
QNLEHLDGMVAPEVCPMETAAYVSSHSS
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| BDBM50078117 |
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| n/a |
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| Name | BDBM50078117 |
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| Synonyms: | (1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL | (1R,2R,3R,4S,5R)-4-Amino-5-methylsulfanyl-cyclopentane-1,2,3-triol | CHEMBL9623 | Mannostatin A, 1 | Mannostatin A, 1a |
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| Type | Small organic molecule |
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| Emp. Form. | C6H13NO3S |
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| Mol. Mass. | 179.237 |
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| SMILES | CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O |
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| Structure | 
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