| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM260404 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1664995 (CHEMBL4014791) |
|---|
| EC50 | 9.6±n/a nM |
|---|
| Citation |  Xu, J; Lin, S; Myers, RW; Trujillo, ME; Pachanski, MJ; Malkani, S; Chen, HS; Chen, Z; Campbell, B; Eiermann, GJ; Elowe, N; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; McMasters, DR; Mitra, K; Tong, X; Xu, L; Zhang, F; Zhang, R; Addona, GH; Berger, JP; Zhang, B; Parmee, ER Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus. Bioorg Med Chem Lett27:2063-2068 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52175.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35557 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
|---|
| BDBM260404 |
|---|
| n/a |
|---|
| Name | BDBM260404 |
|---|
| Synonyms: | US9527838, 32 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H14ClFN4O3S3 |
|---|
| Mol. Mass. | 533.018 |
|---|
| SMILES | OC(=O)Cc1nc(NC(=O)c2nc(Sc3ccccn3)ccc2Sc2ccc(F)cc2)sc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
